Alzheimer disease is a major age-associated neurodegenerative disorder affecting a large percentage of the U.S. population over the age of 70. There are no effective therapies to cure or prevent it, largely due to a lack of understanding of the pathophysiology of the disorder. Although there are some known genetic predispositions to develop AD, the vast majority of cases are sporadic. The causes are multifactorial, but one major contributing factor that has garnered the attention of researchers in recent years is the cumulative damage from increased production of reactive oxygen species (ROS), which include superoxide (O2-) and peroxynitrite (ONOO-), on synapses in the brain that lead to neuron loss. A review article from 2017 gives some background information on the pathophysiology of AD and the purported links to ROS production:
(the above article is open access)
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